7-Day Care Method to Double the Effectiveness of PDRN Salmon Injection

Information as of June 2026

Care Guide to Maximizing Regeneration

• Extends the duration of effects by 30% with care within 72 hours
• Optimal re-treatment cycle: 4-6 weeks
• Twice the difference in regeneration speed with care during the first week

Immediately After Procedure, the 72 Hours When Regenerative Capacity Is Determined

Half of the patients who give up after just a week of receiving PDRN, saying 'there is no significant effect', If you do not apply a cold compress within 6 hours after the procedure, swelling will persist for more than 48 hours, and fibroblasts will not be properly activated during this period.

Caution Washing your face with hot water is strictly prohibited on the day of the procedure. Rinse gently with lukewarm water (30 degrees or lower) to create lather, and remove moisture by patting with a towel. Rubbing may cause bruising to spread at the injection site.

• Cold compress for 10 minutes x 3 times within 6 hours after the procedure → Duration of swelling decreases by 30%
• Fibroblast activity levels are high during the first 72 hours → Inflammation management during this period determines the effectiveness
• Washing with lukewarm water (below 30 degrees) + rinsing with only lather = Stabilization of the injection site

Weekly Care Checklist: From Washing Your Face to Exercise

The first week after the procedure is a critical period during which PDRN settles into the dermis layer and sends regeneration signals. During this period, high-intensity exercise, saunas, and alcohol consumption can drastically increase blood flow, causing the injected ingredients to migrate from their original location. Rinse your face with water only for up to 48 hours, and start using cleansing foam on the third day. It is safe to lather a foaming cleanser in your palms, apply it to your face, and rinse it off within 10 seconds. Scrubs, peels, and exfoliants are prohibited for two weeks. You must switch your cosmetics to focus on moisturizing starting from the day of the procedure. Stop using exfoliating ingredients such as retinol, AHA, and BHA for one week, and switch to products containing ceramide, hyaluronic acid, or panthenol. CICA creams have synergy with PDRN regeneration, so they are frequently recommended in the clinic.

Exercise is permitted only up to a heart rate of 120 or lower. Walking and yoga are fine, but please resume running, weight training, and cycling after one week. Excessive sweating allows bacteria to penetrate the pores, increasing the risk of inflammation.

Alcohol and tobacco are prohibited for at least 72 hours.

Alcohol worsens bruises by dilating blood vessels, and nicotine reduces blood flow, slowing the regeneration rate by more than 30%.

Timing	Cleansing	Cosmetics	Exercise·Lifestyle
Same day~48 hours	Rinse with water only	Moisturizer only (Discontinue retinol)	Cold compress·Rest
3~7 days	Foaming cleanser (within 10 seconds)	Ceramide·Cica Cream	Exercise with a heart rate of 120 or less
8 days to 2 weeks	Normal cleansing is possible	Exfoliation can be resumed	High-intensity exercise can be resumed

Recovery speed may vary depending on individual skin condition.

Retreatment cycle, when is the optimal time?

Research results show that collagen density is highest when PDRN is administered 3 consecutive times at intervals of 4-6 weeks, rather than a single treatment. However, if the interval between re-treatments is within 2 weeks, inflammation may actually accumulate, and if it is longer than 8 weeks, the effects of the previous treatment are diluted. Pharma Research Products, the manufacturer of Rejuran, recommends 3 treatments at 3-week intervals for initial intensive care, followed by maintenance treatments every 2-3 months. In domestic clinical trials, a 4-week interval is the most common, and the rate of fibroblast proliferation reaches its peak when treatments are performed at this cycle. The biggest reason for missing the timing for re-treatment is the misconception that "the effects are still remaining." The regenerative effects of PDRN appear starting from the 2nd week after injection, but the rate of new collagen production decreases after 4 weeks. Additional treatments must be performed at this point to continue the regenerative wave without interruption. The treatment cycle can be adjusted according to age and skin condition. For those in their late 20s to early 30s, a 5-6 week interval is sufficient, but for those 40 years or older, or smokers and diabetic patients, the interval should be shortened to 3-4 weeks. The Ministry of Food and Drug Safety's approval also specifies 'adjusting the interval according to individual skin condition.' Clinical: There are reports that applying a high-concentration vitamin C serum the day before a re-procedure slightly increases the absorption rate of PDRN. However, do not use retinol or AHA, as they weaken the skin barrier and have adverse effects.

• Initial Intensive: 3 times at 3-4 week intervals → Maximize collagen density
• Maintenance: 2-3 times per year at 2-3 month intervals → Long-term effects
• Those 40+ & Smokers: Recommended to shorten to 3-week intervals

Why does the duration of effects vary from person to person?

It is said that even when receiving the same PDRN, some patients say they 'seem to sag again' after 6 months, while others say it after 3 months. The first factor creating this difference is daily UV management. Ultraviolet rays (UVA) activate the MMP-1 (matrix metalloproteinase) enzyme, which breaks down collagen in the dermis. Even collagen newly created with PDRN is lost by more than 20% in just one month if exposed to UV rays without protection. There is an average difference of two months in the duration of effectiveness between patients who apply sunscreen with an SPF of 30 or higher daily and those who do not. The second factor is sleep and protein intake. Fibroblasts synthesize collagen most actively when growth hormone is secreted during sleep. There is a study (Journal of the Korean Dermatological Association 2020) showing that if sleep of six hours or less per day persists for more than two weeks, the regeneration rate decreases by 40%. You must consume at least 0.8g of protein per kilogram of body weight per day to ensure sufficient raw materials for collagen. Consuming high-quality protein such as chicken breast, eggs, and tofu with every meal, along with taking Vitamin C (500mg per day), promotes collagen synthesis. The third step is skin barrier care. Dry skin has a high TEWL (Transepidermal Water Loss), causing PDRN ingredients to evaporate quickly. For two weeks after the procedure, reapply moisturizer at least three times a day to strengthen the skin barrier. Home Care Routine: Habits to Double the Effects of the Procedure The home care most recommended by clinics after PDRN treatment is a hypoallergenic LED mask. Clinical reports indicate that red light with a wavelength of 630nm stimulates fibroblasts to increase collagen production by an additional 20%. However, start using it on the third day after the procedure and limit usage to no more than 10 minutes at a time. Apply Vitamin C serum as the first step after cleansing in the morning. A concentration of 10-15% is appropriate, and the L-ascorbic acid form has the best synergy with PDRN. However, since simultaneous use with retinol can cause skin irritation, please separate your use by taking Vitamin C in the morning and retinol in the evening. Peeling can be resumed 2 weeks after the procedure, but we recommend PHA (Polyhydroxy Acid) instead of AHA. Because PHA has large molecules, it does not penetrate the dermis layer, allowing it to remove dead skin cells without interfering with the PDRN ingredients. Massage is a double-edged sword. A light touch that aids lymphatic circulation is effective, but applying strong pressure can cause the injection site to shift. For two weeks after the procedure, apply only lightly by tapping with your fingertips, and wait one month before using rollers or lifting devices. Tip: After the PDRN procedure, applying the oil serum before the moisturizing cream improves absorption. Rub 2-3 drops of a hypoallergenic oil, such as squalane or jojoba oil, between your palms to warm it with body heat, then apply it to your face by pressing gently. LED Mask (630nm) 3 times a week → 20% increase in collagen production Vitamin C Serum (10-15%) every morning → Antioxidant + regeneration synergy PHA Peeling (after 2 weeks) → Exfoliate while minimizing irritation to the dermis

Key Summary: Priorities of PDRN Care

To maximize the effects of PDRN treatment, prioritize in the following order: Inflammation management for the first 72 hours → Lifestyle control for 1 week → Re-treatment timing for 4-6 weeks → Long-term UV protection. If you miss even one of these four steps, the regeneration speed drops to less than half. The re-treatment cycle can be adjusted according to age, skin condition, and lifestyle patterns, but the initial 3 sessions must be spaced 3-4 weeks apart to ensure collagen density reaches a critical point. Once you move on to the maintenance phase, you can adjust the frequency to every 2-3 months.

• First 72 hours cold compress + lukewarm water cleansing = Securing the foundation for regeneration
• Avoid high-intensity exercise, sauna, and alcohol for 1 week = Ingredient settling
• Initial 3 times (at intervals of 3-4 weeks) → Maintenance (at intervals of 2-3 months) = Long-term effect
• SPF 30 or higher daily + 0.8g/kg protein = Collagen protection

PDRN Post-procedure Care vs. General Care

Post-PDRN Procedure [Intensive Regeneration]

• Cleansing: Water only for 48 hours, Foaming cleanser starting from day 3
• Cosmetics: Discontinue retinol and AHA for 1 week, switch to cica and ceramide
• Exercise: Heart rate 120 or lower, no sauna for 1 week
• UV: SPF 30 or higher required, reapply every 2 hours

The first 72 hours determine 50% of the effect

General Anti-Aging Care [Prevention-oriented]

• Cleansing: Double cleansing, cleansing oil may be used
• Cosmetics: Regular use of retinol and AHA
• Exercise: No restrictions, saunas allowed
• UV: SPF 30, Only when going out

Long-term habits are important

PDRN Management Strategies by Situation

Office workers, frequent lunchtime outings, and difficulty reapplying sunscreen

Apply sunscreen in the morning with a double structure of tone-up + powder, and reapply only powder at lunchtime

Adding just SPF 15 powder extends UV protection by 40%

Exercise routine If you wish to maintain the results

Complete rest for 3 days after the procedure, switch to yoga or Pilates starting on the 4th day, and resume high-intensity exercise on the 8th day

A gradual return is safe because a sudden spike in heart rate causes dispersion at the injection site

For dry skin or high TEWL (transitional water loss)

Switch to a routine of oil serum first → moisturizing cream over it for 2 weeks after the procedure

Oil prevents PDRN evaporation and increases absorption rate by 20%

Those 40 and older, concerned about the re-treatment cycle

The first 3 treatments are spaced 3 weeks apart, then adjusted to 8 weeks thereafter, but re-treatment should be performed immediately if skin elasticity is felt to decrease

As you age, the rate of collagen synthesis slows down, so the interval must be shortened to maintain the effect

Common Misconceptions

Misconception PDRN lasts for 6 months with just one injection

Truth The effect of a single treatment lasts an average of 2-3 months. To maintain the results for more than 6 months, maintenance is required every 2-3 months following the initial 3 intensive treatments. The manufacturer's recommended protocol also specifies '3 consecutive treatments'.

Misconception It is okay to apply makeup immediately after the procedure

Truth There is a risk of inflammation if cosmetic ingredients penetrate the dermis before the needle mark has completely healed. Avoid base makeup for at least 12 hours, and starting 24 hours later, apply only a light mineral cushion.

Absolutely Prohibited Actions After PDRN Procedure

• On the day of the procedure: Wash face with hot water (over 40 degrees), sauna, or steam room
• Use cleansing oil, scrub, or peeling agent within 48 hours
• High-intensity exercise (running, weight training, cycling, etc., heart rate over 120) within 1 week
• Drinking alcohol or smoking within 72 hours (worsens bruising due to vasodilation/constriction)
• Use cosmetics containing exfoliating ingredients such as retinol, AHA, or BHA within 2 weeks
• Rub the treated area vigorously or use massage tools (risk of ingredient migration)

Frequently Asked Questions Questions

When can I wash my face after the PDRN procedure?

You can rinse your face with water only on the same day, but please wait 48 hours before using cleansing foam. It is safe to lather the foam sufficiently in your palms, apply it to your face, and wash it off within 10 seconds. Scrubs and peeling agents are prohibited for 2 weeks.

What is the optimal interval for re-treatment?

For initial intensive care, performing the procedure 3 times at intervals of 3-4 weeks maximizes collagen density. Subsequent maintenance care can be adjusted to intervals of 2-3 months, but for those over 40 or smokers, narrowing the interval to 3 weeks is effective.

When can I apply Vitamin C serum?

You can use it starting from the day of the procedure, and it is actually recommended as it has a synergistic effect with PDRN. However, limit the concentration to 10-15% and avoid simultaneous use with retinol. It is safer to separate your routine with Vitamin C in the morning and retinol in the evening. Do I need to stop exercising completely? You can start heart rate exercises below 120 (walking, yoga) on the same day, but please resume high-intensity exercises such as running, weight training, and cycling after one week. Excessive sweating increases the risk of inflammation as bacteria can penetrate the pores. What are the side effects or symptoms to watch out for after the PDRN procedure? Generally, swelling, bruising, and stinging within 48 hours are normal reactions. However, if swelling persists for more than 3 days or the injection site becomes hot and red, it is a sign of inflammation, so please contact the clinic where the procedure was performed immediately. Rarely, allergic reactions (itching, hives) may occur, in which case a prescription for antihistamines is required.

When do the effects appear?

With PDRN, improvements in skin elasticity begin to be felt starting from the 2nd week after injection, and the effects reach their peak between 4 and 6 weeks. Effects tend to persist beyond 8 weeks with 3 consecutive treatments, compared to a single treatment.

This content is for informational purposes only and does not replace medical advice. PDRN treatment and care methods may vary depending on individual skin conditions, so be sure to consult a specialist before and after the procedure.

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