5 Types of Skin Boosters: Finding the Right Product for You Based on the Skin's Internal Principles

Information as of June 2026

Comparison of Ingredients, Infusion Layer, and Duration

• 12 Domestically Approved Products
• Difference in Infusion Layer: 0.5~4mm
• Duration: 4~12 Months

Is a skin booster different from applying moisturizer?

‘If my skin is dry, can’t I just apply cream diligently?’ If you thought this, you are only halfway there That is correct. Even if the epidermis is replenished, the lack of moisture in the dermis cannot be resolved with cosmetics. Skin boosters are not applied topically; they are a procedure that involves directly injecting them 1 to 3 mm deep into the skin. A representative example is the Restylane Skin Booster, which received FDA approval in 2015. It works on the principle of drawing moisture from within by injecting 20 mg/ml of hyaluronic acid into the middle layer of the dermis. While creams only reach up to 0.1 mm of the epidermis, skin boosters reach the dermis where collagen is produced. There are over 12 types of products currently in use in Korea based on KFDA approval standards. The injection depth and effect vary depending on the ingredients, concentration, and molecular size; if you do not understand these differences, you may choose a product that is not suitable for your skin. Key Point: Only cosmetic moisturizing ingredients with a molecular weight of 500 Da or less can penetrate the epidermis. Skin booster hyaluronic acid has a viscosity of over 1000 kDa, so direct dermal injection is the only route.

• Average epidermal thickness 0.1 mm, dermal 1–4 mm — Target layer for skin booster injection
• 1 g of hyaluronic acid retains 1000 times its own weight in water (Journal of Dermatological Science, 2018)
• Restylane Skin Booster clinical trials reported a 47% increase in moisture after 6 months

What actually happens inside the skin?

When a skin booster is injected, dermal fibroblasts begin to react. Hyaluronic acid-based products attract moisture immediately upon injection, and after 3 to 4 weeks, they stimulate the synthesis of collagen types I and III.

PDRN (Polynucleotide) products are a little different. Like Rejuran, the salmon DNA extract component works on the principle of activating VEGF (Vitamin EGF) to thicken the dermis along with regenerating microvessels. It is closer to tissue reconstruction than hydration. Unlike Botox, which temporarily blocks muscles, skin boosters alter the environment of the dermis itself, so both immediate and delayed effects appear simultaneously. The hydration immediately after the procedure is due to the injected ingredients, while the elasticity 2 to 3 weeks later is due to collagen regeneration. There is a domestic study showing that injecting 2cc of Rejuran increased dermal thickness by an average of 0.3mm (Journal of the Korean Dermatological Association, 2020). It goes beyond simple hydration; it essentially changes the structure itself.

• Collagen Type I is responsible for elasticity, while Type III is responsible for wound healing and regeneration.
• PDRN concentration of 2~5mg/ml is within the MFDS approval range.
• Moisture expansion around the hyaluronic acid begins within 24 hours of injection.

How are skin boosters classified?

They are broadly divided into three types: hyaluronic acid-based, PDRN-based, and complex ingredients. Hyaluronic acid is further subdivided by particle size and whether it is cross-linked.

Non-cross-linked hyaluronic acid (Restylane Vital, Juvederm Volite) has small particles that spread evenly in the upper dermis (0.5~1mm). If your goal is a dewy glow, this is the way to go. Although the duration is relatively short, lasting about 4 to 6 months, the advantage is the immediate radiance right after injection. PDRN products (Rejuran, Rejuran i) are injected into a deeper layer (2 to 3 mm). They are more effective at improving pores, scars, and fine lines than moisture, and last for 8 to 12 months. However, it takes 2 to 3 weeks to feel the effects. Combination types (Chaeum, Belotero) mix hyaluronic acid with amino acids and vitamins to provide both moisture and nutrition simultaneously. This is a type frequently chosen by people in their late 20s to early 30s.

• Non-crosslinked HA has a particle size of 100~300 micrometers
• Average 2~4cc injected per Rejuran treatment
• Combination products contain 5~10% Vitamin C and glutathione

What is the difference between Rejuran and Skin Booster?

Rejuran is also a type of Skin Booster. However, it is called separately because its ingredients and purpose differ from general hyaluronic acid products.

The primary goal of hyaluronic acid Skin Boosters is hydration. You can immediately feel your skin becoming plump and glowing right after the injection. On the other hand, since Rejuran aims for regeneration and recovery, there aren't significant changes immediately after the procedure; instead, pores begin to narrow or fine lines fade starting 2 to 3 weeks later. That is why people in their early to mid-20s often choose hyaluronic acid products, while I tend to recommend Rejuran to those in their 30s or older who have concerns about scars or pores. Some people even get both—using Rejuran for base regeneration and then adding shine with hyaluronic acid. Tip: If you add a hyaluronic acid skin booster 2 weeks after the Rejuran procedure, you can maximize both the regeneration and hydration effects simultaneously. However, duplicate injections in the same area on the same day should be avoided due to the risk of inflammation.

• Rejuran contains salmon DNA-derived PDRN, while hyaluronic acid is derived from bacterial fermentation
• Average cost of Rejuran is 200,000 to 400,000 won, while hyaluronic acid products are in the 150,000 to 300,000 won range
• Regenerative effects last 8 to 12 months for Rejuran and 4 to 6 months for hyaluronic acid

How do I choose the right product for me?

It varies depending on age, skin type, and goals. If you are in your early to mid-20s and are only concerned about dryness, non-crosslinked hyaluronic acid (Restylane Vital) is sufficient. Because the goal is immediate hydration. If you are in your 30s or older, or if you are concerned about enlarged pores, loss of elasticity, and fine lines, PDRN products (Rejuran or Rejuran i) are more effective. Although it takes some time, it changes the structure itself. If you have thin and sensitive skin, look for a combination of low-crosslinked HA and moisturizing ingredients like Belotero Soft. It provides a definite radiance with minimal irritation. If you are on a tight budget, starting with a hyaluronic acid product to check the results, and then upgrading to Rejuran is also an option. You don't need to start with expensive products all at once.

• Skin booster selection ratio for 20s: Hyaluronic acid 72%, PDRN 28%
• For 30s and older: Reversal to Hyaluronic acid 45%, PDRN 55%
• Low-crosslinked products recommended for thin skin (dermis 1mm or less)

Make sure to remember this

Skin Boosters are not a 'one-time finish' but a 'maintenance' concept. Since hyaluronic acid gradually breaks down after 4 to 6 months and PDRN after 8 to 12 months, regular re-treatment is necessary.

If you want to prolong the effects, 2 to 3 intensive treatments within the first 3 months followed by maintenance treatments every 6 months. If you try to last a year after receiving it just once, you might not feel even half the effect. Caution: PDRN products should be avoided if you are pregnant, breastfeeding, or have an autoimmune disease (such as lupus or rheumatism). Please consult with a specialist before deciding on hyaluronic acid products as well.

• The standard protocol is maintenance treatment following intensive treatment (2-3 sessions) during the first 3 months
• Perceived effect level is around 40% with just one session — over 80% with continuous treatment
• The typical re-treatment cycle is 4-6 months for hyaluronic acid and 6-9 months for PDRN
• Determine which product suits your skin by evaluating it 2 weeks after the first treatment — Do not judge too early

Hyaluronic Acid vs. PDRN, 3 Key Differences

Product Selection Guide by Situation

Common Misconceptions

Precautions Before and After Procedure

• !!No drinking, sauna, or high-intensity exercise on the day of the procedure!! — Worsening bruising and swelling due to increased blood flow
• Avoid strong massage or pressure on the injection site for 3 days after the procedure — due to concerns about component migration
• Consult a specialist before deciding if you are pregnant, breastfeeding, or have an autoimmune disease
• Postpone the procedure if you have a keloid tendency or an infected skin area
• If you are taking blood circulation medications such as aspirin or Omega-3, consult a specialist to stop taking them 1 week before the procedure

Frequently Asked Questions

This content is for informational purposes only and does not replace medical advice. You must consult a specialist before the procedure. Suitability and the risk of side effects may vary depending on individual skin condition, medical history, and medications being taken.

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